Selected articles reprinted from 2021, Vol. 21, No. 12; 2022, Vol. 22, No. 2–5 Issue 4 PDAC evolution and heterogeneity Integrating omics data www.nature.com/nrc Massive scope of the problem Smokeless tobacco and cigarette smoking
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NATURE REVIEWS | CANCER 36 Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention Stephen S. Hecht and Dorothy K. Hatsukami This Review discusses carcinogens in smokeless tobacco products and cigarette smoke and biomarkers that may be able to identify those individuals at highest risk of tobacco-related cancers. It also discusses regulation of the levels of carcinogens and nicotine in these products as approaches to cancer prevention. REV I EWS 10 Mapping the genomic diaspora of gastric cancer Khay Guan Yeoh and Patrick Tan This Review discusses recent foundational and translational advances in gastric cancer genomics and epigenomics and highlights how these findings have improved our understanding of basic mechanisms driving gastric cancer biology as well as emerging preclinical targets. 24 Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data Ashton A. Connor and Steven Gallinger This Review outlines our current understanding of the evolution and heterogeneity of pancreatic ductal adenocarcinoma (PDAC), which has advanced owing to the study of preclinical models and patient samples, and presents an evolutionary model of PDAC progression based primarily on genomics studies of human PDAC. CONTENTS NATURE REVIEWS | CANCER VOLUME 22 | MARCH 2022 Nature Reviews Cancer (ISSN1474-175x) is publishedmonthly by Springer Nature Limited, TheCampus, 4|Crinan Street, London N1|9XW, UK. Airfreight andmailing in theUSA by agent namedWNShippingUSA, 156-15, 146thAvenue, 2nd Floor, Jamaica, NY 11434, USA. Periodicals postage paid at Brooklyn, NY 11256. US Postmaster: Send address changes to Springer Nature, WNShippingUSA, 156-15, 146thAvenue, 2nd Floor, Jamaica, NY 11434, USA. Printer andmailer: Printforce (Culemborg, TheNetherlands). Copyright © 2022 Springer Nature Limited. All rights reserved. For the actual version of record please always check the online version of the publication. No|part of this publicationmay be reproduced, stored in a retrieval system, or transmitted in any form (electronic or otherwise) without prior permission frompermissions@ nature.com. www.nature.com/nrc ABOUT US To learnmore about the journal and its publishing practices, visit www.nature.com/nrc/journal-information ORCID We support the use of the persistent digital identifier ORCID tomake content and researchers more discoverable and visible. For more information, go to https://orcid.org/ SUPPLEMENTARY INFORMATION Articles may include online-only supplementary text or display items, which may be referenced separately from the article. TWITTER Follow Nature Reviews Cancer on Twitter for the latest news from the journal and beyond: @NatureRevCancer E-ALERT SIGN-UP Get FREE monthly e-mail alerts to the content of this journal by registering online. Or sign up to receive the latest content as an RSS newsfeed by visiting www.nature.com/nrc COMPETING INTERESTS POLICY Authors of articles in Nature Reviews Cancer are required to declare any|competing interests. For details, please see www.nature.com/authors/policies/competing.html 2-YEAR IMPACT FACTOR 60.716 2-YEAR MEDIAN 42 For more information on journal metrics, please see www.nature.com/npg_/company_info/journal_metrics.html
www.nature.com/nrc CONT ENT S NOVEMBER 2021 | VOLUME 21 www.nature.com/nrc - MEET THE EDITORS EDITORIAL & PRODUCTION OFFICE The Campus, 4 Crinan Street, London N1|9XW, UK Tel: +44 (0)20 7833 4000 | Email: nrc@nature.com www.nature.com/nrc Sarah Seton-Rogers Anna Dart, Ulrike Harjes Lara Crow Matthew Evans Jenny Fosmire Louise O’Reilly Natalie Smith - Katharine Wrighton (Team Leader), Claire Ashworth, Caroline Barranco, Rebecca Kelsey, Isobel Leake, Grant Otto and Joseph Willson (Seniors), Timothy Thomas (Locum Associate) Liesbet Lieben Andrea Monica Jenna Johnston Paul Fletcher Laura Lee Derna Brown Samantha Whitham Kelly Krause Mina Razzak , Ritu Dhand , Ruth Wilson James Butcher Alison Mitchell --, Magdalena Skipper www.nature.com/help subscriptions@nature.com www.nature.com/reprints www.nature.com/advertising www.springernature.com/licensing press@nature.com marketing@nature.com MANAGEMENT OFFICES The Campus, 4 Crinan Street, London, N1|9XW, UK. Tel: +44 (0)20 7833 4000 One New York Plaza, Suite 4500, New York, NY 10004-1562, USA. Tel: +1 212 726 9200 - Shiroyama Trust Tower 5F, 4-3-1 Toranomon, Minato-Ku, Tokyo 105-6005 Japan. Tel: +81 3 4533 8050 A list of other offices can be found at www.nature.com/ npg_/contact/offices.html ▶ : Seeing clearly in 3D, inspired by the Review on p718. Cover design: Lara Crow. CONT ENT S NATUR REVIEWS | CANCER VOLUME 22 | MARCH 2022 - MEET THE EDITORS ▶ : Fields colliding, inspired by the Perspective on p157. Cover design: Lara Crow. M NAG MENT OFFICES The Campus, 4 Crinan S reet, L don, N1|9XW, UK. Tel: +44 (0)20 7833 4000 On New York Plaza, Suite 4500, New York, NY 10004-1562, USA. Tel: +1 212 7 6 9200 - Shiroyama Trust Tower 5F, 4-3-1 Toran mon, Minato-Ku, T kyo 105-6005 Japan. Tel: +81 4533 8050 A list of other offi es can be found at ww.nature.com/ npg_/contact/offices.html EDITORIAL & PRODUCTION OFFICE The Campus, 4 Crinan S reet, L don N1|9XW, UK Tel: +44 (0)20 7833 4000 | Email: nrc@nature.com ww.nature.com/nrc Sarah Seton-Rogers Ann Dart, Ulrike Harjes La a Crow Matthew Evans Jenny Fosmire Louise O’Reilly Natalie Smith - K tharine Wrighton (Team L ader), Claire Ashworth, Caroline Barranco, Lu i Brunello, R becca Kelsey, Isobel Leake, Grant Otto, Jake Rogers, Joseph Willson (Seniors), Mike Attw rs, Hannah Hatcher (Associates), Timothy Thomas (Locum Associate) Liesbet Lieben Georgina Moffat Jenna Johnston Paul Fletcher Laura Lee Stu rt Drake Samantha Whitham Kelly Kr use Mina Razzak , Ruth Wilson James Butcher Alison Mitchell -, M gd lena Skipper ww.nature.com/help ubscriptio s@nature.com ww.nature.com/reprints ww.nature.com/advertising ww.springernature.com/licensing press@nature.com marketing@nature.com Selected articles reprinted from 2021, Vol. 21, No. 12; 2022, Vol. 22, No. 2–5 Issue 4 PDAC evolution and heterogeneity Integrating omics data www.nature.com/nrc Massive scope of the problem Smokeless tobacco and cigarette smoking VIEWPOINT 1 Artificial intelligence in cancer research, diagnosis and therapy Olivier Elemento, Christina Leslie, Johan Lundin and Georgia Tourassi COMMENT 7 Reimagining cancer research with art Dhruba Deb, Stefani Shoreibah and Tal Danino RESEARCH HIGHLIGHTS 9 METASTASIS Naughty neutrophils JOURNAL CLUB Nanotherapy: targeting the tumour microenvironment
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Johnson & Johnson Private Limited Arena Space, BehindMajas Depot, Off J.V. Link Road, Jogeshwari (E), Mumbai-400060 This information is for registered medical practitioners and does not replace the advice or counsel of a doctor or health care professional nor should it be construed to replace the clinical judgement or guide to individual patient care. Furthermore, although the information provided herein is believed to be true and accurate, Janssen, pharma division of Johnson & Johnson Pvt. Ltd., assumes no responsibility in any manner whatsoever, for any action you take, based on the information provided herein. For additional information, contact: Johnson & Johnson Private Limited, Arena Space, Behind Majas Depot, Opp. J.V. Link Road, Jogeshwari (E), Mumbai 400060. Website: www.jnjindia.com With Best compliments from is i f r ti is f r r ist r m i l pr titi rs a d s n t r l t a i or c s l of a d t r or h lt c r r f s i l n r s l it b c str t r l t cli i l j t or g i t i i i l p ti t c r . F rt r r , lt t i f r ti pr i h r i is b li t b tr a a r t , J s , p r di isi of J s & J s t. Lt ., as s n r s si ilit i a m r w ts r, f r a a ti y t , b s o t i f r ti pr i r i . F r a iti l i f r ti , c t t: J s & J s Pri t Li it , Ar S , B i M j s D t, O . J. . i R , J s ri ( ), M i 4 . W sit : w .j ji i . Input code: CP-343876
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